Historian James H. Jones published the first edition of Bad Blood, the definitive history of the Tuskegee Syphilis Experiment, in 1981. Its clear-eyed examination of that research and its implications remains a bioethics classic, and the 30-year anniversary of its publication served as the impetus for the reexamination of research ethics that this symposium presents. Recent revelations about the United States Public Health Service study that infected mental patients and prisoners in Guatemala with syphilis in the late 1940s in (...) order to determine the efficacy of treatment represent only one of the many attestations to the persistence of ongoing, critical, and underaddressed issues in research ethics that Bad Blood first explored. Those issues include, but are not limited to: the complex and contested matters of the value of a given research question, the validity of the clinical trial designed to address it, and the priorities of science. (shrink)

The development of science has been a distinctive feature of human history in recent times, especially in the seventeenth and eighteenth centuries. In light of the problems that define the philosophy of science today, James Fetzer provides a foundation for inquiry into the nature of science, the history of science, and the relationship between the two. In Philosophy of Science, Fetzer investigates the aim and methods of empirical science and examines the importance of methodological commitments to the study of (...) science and the significance of interpretations of probability for understanding laws of nature and scientific explanations. This book offers a welcome framework for investigating the most recent work and the most promising solutions to the central problems that arise within this discipline. The result is a timely introduction to an increasingly important field. -- Publisher description. (shrink)

Perhaps no technological innovation has so dominated the second half of the twentieth century as has the introduction of the programmable computer. It is quite difficult if not impossible to imagine how contemporary affairs—in business and science, communications and transportation, governmental and military activities, for example—could be conducted without the use of computing machines, whose principal contribution has been to relieve us of the necessity for certain kinds of mental exertion. The computer revolution has reduced our mental labors by means (...) of these machines, just as the Industrial Revolution reduced our physical labor by means of other machines. (shrink)

A personal story of the ways in which persistence, chance, and creativity interact in biomedical research. This first book by the author of Zen and the Brain examines the role of chance in the creative process. James Austin tells a personal story of the ways in which persistence, chance, and creativity interact in biomedical research; the conclusions he reaches shed light on the creative process in any field. Austin shows how, in his own investigations, unpredictable events shaped the outcome (...) of his research and brought about novel results. He then goes beyond this story of serendipity to propose a new classification of the varieties of chance, drawing on his own research and examples from the history of science—including the famous accidents that led Fleming to the discovery of penicillin. Finally, he explores the nature of the creative process, considering not only the environmental and neurophysiological correlates of creativity but also the role of intuition in both scientific discoveries and spiritual quests. This updated MIT Press paperback edition includes a new introduction and recent material on medical research, creativity, and spirituality. (shrink)

Taking Brian Cantwell Smith’s study, “Limits of Correctness in Computers,” as its point of departure, this article explores the role of models in computer science. Smith identifies two kinds of models that play an important role, where specifications are models of problems and programs are models of possible solutions. Both presuppose the existence of conceptualizations as ways of conceiving the world “in certain delimited ways.” But high-level programming languages also function as models of virtual (or abstract) machines, while low-level programming (...) languages function as models of causal (or physical) machines. The resulting account suggests that sets of models embedded within models are indispensable for computer programming. (shrink)

On some accounts, early reflection on the nature of human cognition focused on its physical or physiological causes (as, for example, when in fragment 105 Empedocles identifies thought with blood). On other accounts, there was an identifiable process of semantic development in which a number of perception-oriented terms for knowing (e.g. gignôskô, oida, noeô, and suniêmi) took on a more intellectual orientation. Although some find evidence of this transition in the poems of Solon and Archilochus, appreciation for a distinction between (...) sensing and knowing is more plausibly credited to the Presocratic thinkers Heraclitus and Parmenides. It is unclear whether Heraclitus regarded sense perception as an essential first stage in acquiring knowledge (or an inherently inferior form of awareness), but the goddess in Parmenides’ poem unambiguously urges the youth to whom she speaks to set aside the testimony of eye and ear and instead ‘judge by reason’ the nature of what-is. (shrink)

The purpose of this paper is to explore three alternative frameworks for understanding the nature of language and mentality, which accent syntactical, semantical, and pragmatical aspects of the phenomena with which they are concerned, respectively. Although the computational conception currently exerts considerable appeal, its defensibility appears to hinge upon an extremely implausible theory of the relation of form to content. Similarly, while the representational approach has much to recommend it, its range is essentially restricted to those units of language that (...) can be understood in terms of undefined units. Thus, the only alternative among these three that can account for the meaning of primitive units of language is one emphasizing the basic role of skills, habits, and tendencies in relating signs and dispositions. (shrink)

Hempel was one of the most influential philosophers of science in the 20th century, along with Thomas Kuhn and Sir Karl Popper. His work defined the central problems of the field and its proper methods of investigation. By presenting an analytical and historical introduction and a comprehensive bibliography together with a selection of many of Carl G. Hempel's most important studies, this volume provides an ideal opportunity for students and scholars to appreciate the enduring contributions of one of the most (...) important philosophers of science of the 20th century. (shrink)

The purpose of this paper is to provide a systematic appraisal of the covering law and statistical relevance theories of statistical explanation advanced by Carl G. Hempel and by Wesley C. Salmon, respectively. The analysis is intended to show that the difference between these accounts is inprinciple analogous to the distinction between truth and confirmation, where Hempel's analysis applies to what is taken to be the case and Salmon's analysis applies to what is the case. Specifically, it is argued (a) (...) that statistical explanations exhibit the nomic expectability of their explanandum events, which in some cases may be strong but in other cases will not be; (b) that the statistical relevance criterion is more fundamental than the requirement of maximal specificity and should therefore displace it; and, (c) that if statistical explanations are to be envisioned as inductive arguments at all, then only in a qualified sense since, in particular, the requirement of high inductive probability between explanans and explanandum must be abandoned. (shrink)

My purpose here is to elaborate the reasons I maintain that Salmon has not been completely successful in reporting the history of work on explanation. The most important limitation of his account is that it does not emphasize the critical necessity to embrace a suitable conception of probability in the development of the theory of probabilistic explanation.

Based on the Zen philosophy about focusing away from the self, a guide to "neural Zen" meditative practices draws on recent findings in brain research to outline recommendations for various methods of pursuing a balanced, selfless state of ...

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The standard interpretation of the imitation game is defended over the rival gender interpretation though it is noted that Turing himself proposed several variations of his imitation game. The Turing test is then justified as an inductive test not as an operational definition as commonly suggested. Turing's famous prediction about his test being passed at the 70% level is disconfirmed by the results of the Loebner 2000 contest and the absence of any serious Turing test competitors from AI on the (...) horizon. But, reports of the death of the Turing test and AI are premature. AI continues to flourish and the test continues to play an important philosophical role in AI. Intelligence attribution, methodological, and visionary arguments are given in defense of a continuing role for the Turing test. With regard to Turing's predictions one is disconfirmed, one is confirmed, but another is still outstanding. (shrink)

We need to clarify at least four aspects of selfhood if we are to reach a better understanding of consciousness in general, and of its alternate states. First, how did we develop our self-centred psychophysiology? Second, can the four familiar lobes of the brain alone serve, if only as preliminary landmarks of convenience, to help understand the functions of our many self-referent networks? Third, what could cause one's former sense of self to vanish from the mental field during an extraordinary (...) state of consciousness? Fourth, when a person's physical and psychic self do drop off briefly, how has conscious experience then been transformed? In particular, what happens to that subject's personal sense of time? Our many-sided self arose in widely distributed brain networks. Since infancy, these self-oriented circuits have been over-conditioned by limbic biases. Selfhood then seems to have evolved along lines suggesting at least in shorthand the operations of a kind of ‘I-Me-Mine’ complex. But what happens when this egocentric triad briefly dissolves? Novel states of consciousness emerge. Two personally-observed states are discussed: insight-wisdom ; internal absorption. How do these two states differ phenomenologically? The physiological processes briefly suggested here emphasize shifts in deeper systems, and pivotal roles for thalamo-cortical interactions in the front and back of the brain. (shrink)

One of the fundamental and seemingly simple aims of mathematical knowledge management (MKM) is to develop and standardize formats that allow to “represent the meaning of the objects of mathematics”. The open formats OpenMath and MathML address this, but differ subtly in syntax, rigor, and structural viewpoints (notably over calculus). To avoid fragmentation and smooth out interoperability obstacles, effort is under way to align them into a joint format OpenMath/MathML 3. We illustrate the issues that come up in such an (...) alignment by looking at three main areas: bound variables and conditions, calculus (which relates to the previous) and “lifted” n-ary operators. (shrink)

Fix a countable nonstandard model M of Peano arithmetic. Even with some rather severe restrictions placed on the types of minimal cofinal extensions N≻M that are allowed, we still find that there are 2ℵ0 possible theories of (N,M) for such N’s.

It is a commonplace in our histories of Greek philosophy that the first thinker to fashion deductive arguments was Parmenides of Elea. One corollary of this view is that Ionian philosophers before Parmenides provided no arguments in support of their views. In what follows I offer a critique of this dismissive characterization, focusing on the first thinker for whom we have a substantial body of evidence, Xenophanes of Colophon. Specifically, Xenophanes argued that retelling the old stories of divine strife and (...) warfare was out of keeping with the qualities of cleanliness and purity considered essential to a proper symposium. He held also that the presence of fossilized remains at inland and mountainous locations was best explained by positing cycles of worldwide flooding and drought, and he linked many other phenomena with the presence of earth and/or water. He also distinguished between having direct perceptual access to events and knowing the clear and sure truth about them, and concluded that about far-off matters such as the gods and the nature of all things no man can know the certain truth. He held also that a series of contrasts between divine and human attributes followed from an initial assumption of divine greatness. (shrink)